APOE ?2 is associated with white matter hyperintensity volume in CADASIL.
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ABSTRACT:
SUBMITTER: Gesierich B
PROVIDER: S-EPMC4758562 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Publications
APOE ɛ2 is associated with white matter hyperintensity volume in CADASIL.
Gesierich Benno B Opherk Christian C Rosand Jonathan J Gonik Mariya M Malik Rainer R Jouvent Eric E Hervé Dominique D Adib-Samii Poneh P Bevan Steve S Pianese Luigi L Silvestri Serena S Dotti Maria T MT De Stefano Nicola N van der Grond Jeroen J Boon Elles M J EM Pescini Francesca F Rost Natalia N Pantoni Leonardo L Oberstein Saskia A Lesnik SA Federico Antonio A Ragno Michele M Markus Hugh S HS Tournier-Lasserve Elisabeth E Chabriat Hugues H Dichgans Martin M Duering Marco M Ewers Michael M
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20160101 1
Apolipoprotein E (APOE) increases the risk for Alzheimer’s disease (ɛ4 allele) and cerebral amyloid angiopathy (ɛ2 and ɛ4), but its role in small vessel disease (SVD) is debated. Here we studied the effects of APOE on white matter hyperintensity volume (WMHV) in CADASIL (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy), a nonamyloidogenic angiopathy and inherited early-onset form of pure SVD. Four hundred and eighty-eight subjects were recruited through ...[more]
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