SETD7 Regulates the Differentiation of Human Embryonic Stem Cells.

ABSTRACT: The successful use of specialized cells in regenerative medicine requires an optimization in the differentiation protocols that are currently used. Understanding the molecular events that take place during the differentiation of human pluripotent cells is essential for the improvement of these protocols and the generation of high quality differentiated cells. In an effort to understand the molecular mechanisms that govern differentiation we identify the methyltransferase SETD7 as highly induced during the differentiation of human embryonic stem cells and differentially expressed between induced pluripotent cells and somatic cells. Knock-down of SETD7 causes differentiation defects in human embryonic stem cell including delay in both the silencing of pluripotency-related genes and the induc

SUBMITTER: Castano J 

PROVIDER: S-EPMC4758617 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature