Ontology highlight
ABSTRACT:
SUBMITTER: Lee J
PROVIDER: S-EPMC4758873 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Cell reports 20160204 6
Ambient temperature affects energy intake and expenditure to maintain homeostasis in a continuously fluctuating environment. Here, mice with an adipose-specific defect in fatty acid oxidation (Cpt2(A-/-)) were subjected to varying temperatures to determine the role of adipose bioenergetics in environmental adaptation and body weight regulation. Microarray analysis of mice acclimatized to thermoneutrality revealed that Cpt2(A-/-) interscapular brown adipose tissue (BAT) failed to induce the expre ...[more]