Gastric Helicobacter pylori Infection Affects Local and Distant Microbial Populations and Host Responses.
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ABSTRACT:
SUBMITTER: Kienesberger S
PROVIDER: S-EPMC4758874 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Publications
Gastric Helicobacter pylori Infection Affects Local and Distant Microbial Populations and Host Responses.
Kienesberger Sabine S Cox Laura M LM Livanos Alexandra A Zhang Xue-Song XS Chung Jennifer J Perez-Perez Guillermo I GI Gorkiewicz Gregor G Zechner Ellen L EL Blaser Martin J MJ
Cell reports 20160204 6
Helicobacter pylori is a late-in-life human pathogen with potential early-life benefits. Although H. pylori is disappearing from the human population, little is known about the influence of H. pylori on the host's microbiota and immunity. Studying the interactions of H. pylori with murine hosts over 6 months, we found stable colonization accompanied by gastric histologic and antibody responses. Analysis of gastric and pulmonary tissues revealed increased expression of multiple immune response ge ...[more]
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