Ontology highlight
ABSTRACT:
SUBMITTER: Dias JD
PROVIDER: S-EPMC4758952 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Dias João D JD Rito Tiago T Torlai Triglia Elena E Kukalev Alexander A Ferrai Carmelo C Chotalia Mita M Brookes Emily E Kimura Hiroshi H Pombo Ana A
eLife 20151219
Dynamic post-translational modification of RNA polymerase II (RNAPII) coordinates the co-transcriptional recruitment of enzymatic complexes that regulate chromatin states and processing of nascent RNA. Extensive phosphorylation of serine residues at the largest RNAPII subunit occurs at its structurally-disordered C-terminal domain (CTD), which is composed of multiple heptapeptide repeats with consensus sequence Y1-S2-P3-T4-S5-P6-S7. Serine-5 and Serine-7 phosphorylation mark transcription initia ...[more]