Acoustic resolution photoacoustic Doppler velocimetry in blood-mimicking fluids.

ABSTRACT: Photoacoustic Doppler velocimetry provides a major opportunity to overcome limitations of existing blood flow measuring methods. By enabling measurements with high spatial resolution several millimetres deep in tissue, it could probe microvascular blood flow abnormalities characteristic of many different diseases. Although previous work has demonstrated feasibility in solid phantoms, measurements in blood have proved significantly more challenging. This difficulty is commonly attributed to the requirement that the absorber spatial distribution is heterogeneous relative to the minimum detectable acoustic wavelength. By undertaking a rigorous study using blood-mimicking fluid suspensions of 3 μm absorbing microspheres, it was discovered that the perceived heterogeneity is not only limited by

SUBMITTER: Brunker J 

PROVIDER: S-EPMC4759580 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature