Molecular Epidemiology of Rhinovirus Detections in Young Children.

ABSTRACT: Background.  Human rhinoviruses (HRVs) are frequently detected in children with acute respiratory illnesses (ARIs) but also in asymptomatic children. We compared features of ARI with HRV species (A, B, C) and determined genotypes associated with repeated HRV detections within individuals. Methods.  We used clinical data and respiratory samples obtained from children <3 years old during weekly active household-based surveillance. A random subset of samples in which HRV was detected from individuals during both ARI and an asymptomatic period within 120 days of the ARI were genotyped. Features of ARI were compared among HRV species. Concordance of genotype among repeated HRV detections within individuals was assessed. Results.  Among 207 ARI samples sequenced, HRV-A, HRV-B, and HRV-C were det

SUBMITTER: Howard LM 

PROVIDER: S-EPMC4759584 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature