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Genome-wide analysis of genetic correlation in dementia with Lewy bodies, Parkinson's and Alzheimer's diseases.


ABSTRACT: The similarities between dementia with Lewy bodies (DLB) and both Parkinson's disease (PD) and Alzheimer's disease (AD) are many and range from clinical presentation, to neuropathological characteristics, to more recently identified, genetic determinants of risk. Because of these overlapping features, diagnosing DLB is challenging and has clinical implications since some therapeutic agents that are applicable in other diseases have adverse effects in DLB. Having shown that DLB shares some genetic risk with PD and AD, we have now quantified the amount of sharing through the application of genetic correlation estimates, and show that, from a purely genetic perspective, and excluding the strong association at the APOE locus, DLB is equally correlated to AD and PD.

SUBMITTER: Guerreiro R 

PROVIDER: S-EPMC4759606 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature

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Genome-wide analysis of genetic correlation in dementia with Lewy bodies, Parkinson's and Alzheimer's diseases.

Guerreiro Rita R   Escott-Price Valentina V   Darwent Lee L   Parkkinen Laura L   Ansorge Olaf O   Hernandez Dena G DG   Nalls Michael A MA   Clark Lorraine L   Honig Lawrence L   Marder Karen K   van der Flier Wiesje W   Holstege Henne H   Louwersheimer Eva E   Lemstra Afina A   Scheltens Philip P   Rogaeva Ekaterina E   St George-Hyslop Peter P   Londos Elisabet E   Zetterberg Henrik H   Ortega-Cubero Sara S   Pastor Pau P   Ferman Tanis J TJ   Graff-Radford Neill R NR   Ross Owen A OA   Barber Imelda I   Braae Anne A   Brown Kristelle K   Morgan Kevin K   Maetzler Walter W   Berg Daniela D   Troakes Claire C   Al-Sarraj Safa S   Lashley Tammaryn T   Compta Yaroslau Y   Revesz Tamas T   Lees Andrew A   Cairns Nigel J NJ   Halliday Glenda M GM   Mann David D   Pickering-Brown Stuart S   Powell John J   Lunnon Katie K   Lupton Michelle K MK   Dickson Dennis D   Hardy John J   Singleton Andrew A   Bras Jose J  

Neurobiology of aging 20151102


The similarities between dementia with Lewy bodies (DLB) and both Parkinson's disease (PD) and Alzheimer's disease (AD) are many and range from clinical presentation, to neuropathological characteristics, to more recently identified, genetic determinants of risk. Because of these overlapping features, diagnosing DLB is challenging and has clinical implications since some therapeutic agents that are applicable in other diseases have adverse effects in DLB. Having shown that DLB shares some geneti  ...[more]

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