Ontology highlight
ABSTRACT:
SUBMITTER: Georgiadis C
PROVIDER: S-EPMC4759620 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Georgiadis Christos C Syed Farhatullah F Petrova Anastasia A Abdul-Wahab Alya A Lwin Su M SM Farzaneh Farzin F Chan Lucas L Ghani Sumera S Fleck Roland A RA Glover Leanne L McMillan James R JR Chen Mei M Thrasher Adrian J AJ McGrath John A JA Di Wei-Li WL Qasim Waseem W
The Journal of investigative dermatology 20160101 1
Cells therapies, engineered to secrete replacement proteins, are being developed to ameliorate otherwise debilitating diseases. Recessive dystrophic epidermolysis bullosa (RDEB) is caused by defects of type VII collagen, a protein essential for anchoring fibril formation at the dermal-epidermal junction. Whereas allogeneic fibroblasts injected directly into the dermis can mediate transient disease modulation, autologous gene-modified fibroblasts should evade immunological rejection and support s ...[more]