Ontology highlight
ABSTRACT:
SUBMITTER: Lin YT
PROVIDER: S-EPMC4759790 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Journal of the Royal Society, Interface 20160101 114
The dynamics of short-lived mRNA results in bursts of protein production in gene regulatory networks. We investigate the propagation of bursting noise between different levels of mathematical modelling and demonstrate that conventional approaches based on diffusion approximations can fail to capture bursting noise. An alternative coarse-grained model, the so-called piecewise deterministic Markov process (PDMP), is seen to outperform the diffusion approximation in biologically relevant parameter ...[more]