Comparative analysis of plant immune receptor architectures uncovers host proteins likely targeted by pathogens.

ABSTRACT:

Background

Plants deploy immune receptors to detect pathogen-derived molecules and initiate defense responses. Intracellular plant immune receptors called nucleotide-binding leucine-rich repeat (NLR) proteins contain a central nucleotide-binding (NB) domain followed by a series of leucine-rich repeats (LRRs), and are key initiators of plant defense responses. However, recent studies demonstrated that NLRs with non-canonical domain architectures play an important role in plant immunity. These composite immune receptors are thought to arise from fusions between NLRs and additional domains that serve as "baits" for the pathogen-derived effector proteins, thus enabling pathogen recognition. Several names have been proposed to describe these proteins, including "integrated decoys" and "

SUBMITTER: Sarris PF 

PROVIDER: S-EPMC4759884 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature