Genetic influences on trajectories of systolic blood pressure across childhood and adolescence.

ABSTRACT:

Background

Blood pressure (BP) tends to increase across childhood and adolescence, but the genetic influences on rates of BP change are not known. Potentially important genetic influences could include genetic variants identified in genome-wide association studies of adults as being associated with BP, height, and body mass index. Understanding the contribution of these genetic variants to changes in BP across childhood and adolescence could yield understanding into the life course development of cardiovascular risk.

Methods and results

Pooling data from 2 cohorts (the Avon Longitudinal Study of Parents and Children [n=7013] and the Western Australian Pregnancy Cohort [n=1459]), we examined the associations of allelic scores of 29 single-nucleotide polymorphisms (SNPs) for a

SUBMITTER: Howe LD 

PROVIDER: S-EPMC4759925 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature