Ontology highlight
ABSTRACT:
SUBMITTER: Tarcic O
PROVIDER: S-EPMC4761112 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Cell reports 20160204 6
Factors linking inflammation and cancer are of great interest. We now report that the chromatin-targeting E3 ubiquitin ligase RNF20/RNF40, driving histone H2B monoubiquitylation (H2Bub1), modulates inflammation and inflammation-associated cancer in mice and humans. Downregulation of RNF20 and H2Bub1 favors recruitment of p65-containing nuclear factor κB (NF-κB) dimers over repressive p50 homodimers and decreases the heterochromatin mark H3K9me3 on a subset of NF-κB target genes to augment their ...[more]