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Adipose-Derived Stem Cells for Tissue Engineering and Regenerative Medicine Applications.

ABSTRACT: Adipose-derived stem cells (ASCs) are a mesenchymal stem cell source with properties of self-renewal and multipotential differentiation. Compared to bone marrow-derived stem cells (BMSCs), ASCs can be derived from more sources and are harvested more easily. Three-dimensional (3D) tissue engineering scaffolds are better able to mimic the in vivo cellular microenvironment, which benefits the localization, attachment, proliferation, and differentiation of ASCs. Therefore, tissue-engineered ASCs are recognized as an attractive substitute for tissue and organ transplantation. In this paper, we review the characteristics of ASCs, as well as the biomaterials and tissue engineering methods used to proliferate and differentiate ASCs in a 3D environment. Clinical applications of tissue-engineered ASCs are also discussed to reveal the potential and feasibility of using tissue-engineered ASCs in regenerative medicine.

SUBMITTER: Dai R

PROVIDER: S-EPMC4761677 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature

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Adipose-Derived Stem Cells for Tissue Engineering and Regenerative Medicine Applications.

Dai Ru R Wang Zongjie Z Samanipour Roya R Koo Kyo-In KI Kim Keekyoung K

Stem cells international 20160221

Adipose-derived stem cells (ASCs) are a mesenchymal stem cell source with properties of self-renewal and multipotential differentiation. Compared to bone marrow-derived stem cells (BMSCs), ASCs can be derived from more sources and are harvested more easily. Three-dimensional (3D) tissue engineering scaffolds are better able to mimic the in vivo cellular microenvironment, which benefits the localization, attachment, proliferation, and differentiation of ASCs. Therefore, tissue-engineered ASCs are ...[more]

PMID: 27057174

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