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Prognostic role of Gli1 expression in solid malignancies: a meta-analysis.


ABSTRACT: Gli1 is a downstream transcriptional factor of Sonic hedgehog pathway in mammalians, and has been recognized as a proliferative indicator of carcinogenesis. However, its actual role in prognosis among solid malignancies remains unclear. Therefore we performed this meta-analysis aiming to discover the correlation between Gli1 positivity and clinical prognosis in patients suffering from diverse carcinomas. A total of 39 studies containing 4496 cases were selected into our quantitative analysis via electronic database search. Original data of 3-year, 5-year, 10-year overall survival and disease-free survival were extracted and calculated using odds ratio and Mantel-Haenszel model. Subgroup analysis was also conducted to clarify the possible confounding factors. P?

SUBMITTER: Cheng J 

PROVIDER: S-EPMC4762019 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature

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Prognostic role of Gli1 expression in solid malignancies: a meta-analysis.

Cheng Ji J   Gao Jinbo J   Tao Kaixiong K  

Scientific reports 20160222


Gli1 is a downstream transcriptional factor of Sonic hedgehog pathway in mammalians, and has been recognized as a proliferative indicator of carcinogenesis. However, its actual role in prognosis among solid malignancies remains unclear. Therefore we performed this meta-analysis aiming to discover the correlation between Gli1 positivity and clinical prognosis in patients suffering from diverse carcinomas. A total of 39 studies containing 4496 cases were selected into our quantitative analysis via  ...[more]

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