Ontology highlight
ABSTRACT:
SUBMITTER: Neafsey DE
PROVIDER: S-EPMC4762279 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Neafsey D E DE Juraska M M Bedford T T Benkeser D D Valim C C Griggs A A Lievens M M Abdulla S S Adjei S S Agbenyega T T Agnandji S T ST Aide P P Anderson S S Ansong D D Aponte J J JJ Asante K P KP Bejon P P Birkett A J AJ Bruls M M Connolly K M KM D'Alessandro U U Dobaño C C Gesase S S Greenwood B B Grimsby J J Tinto H H Hamel M J MJ Hoffman I I Kamthunzi P P Kariuki S S Kremsner P G PG Leach A A Lell B B Lennon N J NJ Lusingu J J Marsh K K Martinson F F Molel J T JT Moss E L EL Njuguna P P Ockenhouse C F CF Ogutu B Ragama BR Otieno W W Otieno L L Otieno K K Owusu-Agyei S S Park D J DJ Pellé K K Robbins D D Russ C C Ryan E M EM Sacarlal J J Sogoloff B B Sorgho H H Tanner M M Theander T T Valea I I Volkman S K SK Yu Q Q Lapierre D D Birren B W BW Gilbert P B PB Wirth D F DF
The New England journal of medicine 20151021 21
<h4>Background</h4>The RTS,S/AS01 vaccine targets the circumsporozoite protein of Plasmodium falciparum and has partial protective efficacy against clinical and severe malaria disease in infants and children. We investigated whether the vaccine efficacy was specific to certain parasite genotypes at the circumsporozoite protein locus.<h4>Methods</h4>We used polymerase chain reaction-based next-generation sequencing of DNA extracted from samples from 4985 participants to survey circumsporozoite pr ...[more]