Ontology highlight
ABSTRACT:
SUBMITTER: Kantidakis T
PROVIDER: S-EPMC4762426 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Kantidakis Theodoros T Kantidakis Theodoros T Saponaro Marco M Mitter Richard R Horswell Stuart S Kranz Andrea A Boeing Stefan S Aygün Ozan O Kelly Gavin P GP Matthews Nik N Stewart Aengus A Stewart A Francis AF Svejstrup Jesper Q JQ
Genes & development 20160201 4
Genome instability is a recurring feature of tumorigenesis. Mutation in MLL2, encoding a histone methyltransferase, is a driver in numerous different cancer types, but the mechanism is unclear. Here, we present evidence that MLL2 mutation results in genome instability. Mouse cells in which MLL2 gene deletion can be induced display elevated levels of sister chromatid exchange, gross chromosomal aberrations, 53BP1 foci, and micronuclei. Human MLL2 knockout cells are characterized by genome instabi ...[more]