Coagulation factor X activates innate immunity to human species C adenovirus.
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ABSTRACT:
SUBMITTER: Doronin K
PROVIDER: S-EPMC4762479 | biostudies-literature | 2012 Nov
REPOSITORIES: biostudies-literature
Publications
Coagulation factor X activates innate immunity to human species C adenovirus.
Doronin Konstantin K Flatt Justin W JW Flatt Justin W JW Di Paolo Nelson C NC Khare Reeti R Kalyuzhniy Oleksandr O Acchione Mauro M Sumida John P JP Ohto Umeharu U Shimizu Toshiyuki T Akashi-Takamura Sachiko S Miyake Kensuke K MacDonald James W JW Bammler Theo K TK Beyer Richard P RP Farin Frederico M FM Stewart Phoebe L PL Shayakhmetov Dmitry M DM
Science (New York, N.Y.) 20120927 6108
Although coagulation factors play a role in host defense for "living fossils" such as horseshoe crabs, the role of the coagulation system in immunity in higher organisms remains unclear. We modeled the interface of human species C adenovirus (HAdv) interaction with coagulation factor X (FX) and introduced a mutation that abrogated formation of the HAdv-FX complex. In vivo genome-wide transcriptional profiling revealed that FX-binding-ablated virus failed to activate a distinct network of nuclear ...[more]
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