Ontology highlight
ABSTRACT:
SUBMITTER: Zhang WJ
PROVIDER: S-EPMC4763200 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Zhang Wen-juan WJ Wu Xiao-nan XN Shi Tao-tao TT Xu Huan-teng HT Yi Jia J Shen Hai-feng HF Huang Ming-feng MF Shu Xing-yi XY Wang Fei-fei FF Peng Bing-ling BL Xiao Rong-quan RQ Gao Wei-wei WW Ding Jian-cheng JC Liu Wen W
Scientific reports 20160223
Yin Yang 1 (YY1) is a multifunctional transcription factor shown to be critical in a variety of biological processes. Although it is regulated by multiple types of post-translational modifications (PTMs), whether YY1 is methylated, which enzyme methylates YY1, and hence the functional significance of YY1 methylation remains completely unknown. Here we reported the first methyltransferase, SET7/9 (KMT7), capable of methylating YY1 at two highly conserved lysine (K) residues, K173 and K411, locate ...[more]