Ontology highlight
ABSTRACT:
SUBMITTER: Dorfmueller S
PROVIDER: S-EPMC4763205 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Scientific reports 20160223
Cell surface antigens are important targets for monoclonal antibodies, but they are often difficult to work with due to their association with the cell membrane. Phage display is a versatile technique that can be applied to generate binders against difficult targets. Here we used antibody phage display to isolate a binder for a rare and specialized cell, the human corneal endothelial cell. The human corneal endothelium is a medically important cell layer; defects in this layer account for about ...[more]