2D Representation of Transcriptomes by t-SNE Exposes Relatedness between Human Tissues.
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ABSTRACT:
SUBMITTER: Taskesen E
PROVIDER: S-EPMC4764374 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Publications
2D Representation of Transcriptomes by t-SNE Exposes Relatedness between Human Tissues.
Taskesen Erdogan E Reinders Marcel J T MJ
PloS one 20160223 2
The GTEx Consortium reported that hierarchical clustering of RNA profiles from 25 unique tissue types among 1641 individuals accurately distinguished the tissue types, but a multidimensional scaling failed to generate a 2D projection of the data that separates tissue-subtypes. In this study we show that a projection by t-Distributed Stochastic Neighbor Embedding is in line with the cluster analysis which allows a more detailed examination and visualization of human tissue relationships. ...[more]
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