Interleukin-17A Is Associated With Alveolar Inflammation and Poor Outcomes in Acute Respiratory Distress Syndrome.

ABSTRACT:

Objective

Interleukin-17A is a proinflammatory cytokine known to play a role in host defense and pathologic inflammation in murine models of lung injury. The relationship between interleukin-17A and inflammation in human lung injury is unknown. Our primary objective was to determine whether interleukin-17A levels are associated with alveolar measures of inflammation and injury in patients with acute respiratory distress syndrome. Our secondary objective was to test whether interleukin-17A levels are associated with acute respiratory distress syndrome-related outcomes.

Design

Observational study.

Setting

Six North American medical centers.

Patients

We studied two groups of patients with acute respiratory distress syndrome: 1) patients previously enrolled in a pl

SUBMITTER: Mikacenic C 

PROVIDER: S-EPMC4764422 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature