Ontology highlight
ABSTRACT:
SUBMITTER: Poliak S
PROVIDER: S-EPMC4764565 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
eLife 20151203
During neural circuit assembly, axonal growth cones are exposed to multiple guidance signals at trajectory choice points. While axonal responses to individual guidance cues have been extensively studied, less is known about responses to combination of signals and underlying molecular mechanisms. Here, we studied the convergence of signals directing trajectory selection of spinal motor axons entering the limb. We first demonstrate that Netrin-1 attracts and repels distinct motor axon populations, ...[more]