Ontology highlight
ABSTRACT:
SUBMITTER: Oishi K
PROVIDER: S-EPMC4764574 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Oishi Koji K Nakagawa Nao N Tachikawa Kashiko K Sasaki Shinji S Aramaki Michihiko M Hirano Shinji S Yamamoto Nobuhiko N Yoshimura Yumiko Y Nakajima Kazunori K
eLife 20160212
Many cell-intrinsic mechanisms have been shown to regulate neuronal subtype specification in the mammalian neocortex. However, how much cell environment is crucial for subtype determination still remained unclear. Here, we show that knockdown of Protocadherin20 (Pcdh20), which is expressed in post-migratory neurons of layer 4 (L4) lineage, caused the cells to localize in L2/3. The ectopically positioned "future L4 neurons" lost their L4 characteristics but acquired L2/3 characteristics. Knockdow ...[more]