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The chemokine CXCL13 in lung cancers associated with environmental polycyclic aromatic hydrocarbons pollution.


ABSTRACT: More than 90% of lung cancers are caused by cigarette smoke and air pollution, with polycyclic aromatic hydrocarbons (PAHs) as key carcinogens. In Xuanwei City of Yunnan Province, the lung cancer incidence is among the highest in China, attributed to smoky coal combustion-generated PAH pollution. Here, we screened for abnormal inflammatory factors in non-small cell lung cancers (NSCLCs) from Xuanwei and control regions (CR) where smoky coal was not used, and found that a chemokine CXCL13 was overexpressed in 63/70 (90%) of Xuanwei NSCLCs and 44/71 (62%) of smoker and 27/60 (45%) of non-smoker CR patients. CXCL13 overexpression was associated with the region Xuanwei and cigarette smoke. The key carcinogen benzo(a)pyrene (BaP) induced CXCL13 production in lung epithelial cells and in mice prior to development of detectable lung cancer. Deficiency in Cxcl13 or its receptor, Cxcr5, significantly attenuated BaP-induced lung cancer in mice, demonstrating CXCL13's critical role in PAH-induced lung carcinogenesis.

SUBMITTER: Wang GZ 

PROVIDER: S-EPMC4764582 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature

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The chemokine CXCL13 in lung cancers associated with environmental polycyclic aromatic hydrocarbons pollution.

Wang Gui-Zhen GZ   Cheng Xin X   Zhou Bo B   Wen Zhe-Sheng ZS   Huang Yun-Chao YC   Chen Hao-Bin HB   Li Gao-Feng GF   Huang Zhi-Liang ZL   Zhou Yong-Chun YC   Feng Lin L   Wei Ming-Ming MM   Qu Li-Wei LW   Cao Yi Y   Zhou Guang-Biao GB  

eLife 20151113


More than 90% of lung cancers are caused by cigarette smoke and air pollution, with polycyclic aromatic hydrocarbons (PAHs) as key carcinogens. In Xuanwei City of Yunnan Province, the lung cancer incidence is among the highest in China, attributed to smoky coal combustion-generated PAH pollution. Here, we screened for abnormal inflammatory factors in non-small cell lung cancers (NSCLCs) from Xuanwei and control regions (CR) where smoky coal was not used, and found that a chemokine CXCL13 was ove  ...[more]

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