Ontology highlight
ABSTRACT:
SUBMITTER: Gagne D
PROVIDER: S-EPMC4764873 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Gagné Donald D Doucet Nicolas N
Biomolecular NMR assignments 20140717 1
Human ribonuclease 4 (RNase 4) is the most evolutionarily conserved member of the 8 canonical human pancreatic-like RNases, showing more than 90% identity with bovine and porcine homologues. The enzyme displays ribonucleolytic activity with a strong preference for uracil-containing RNA substrates, a feature only shared with human eosinophil derived-neurotoxin (EDN, or RNase 2) and eosinophil cationic protein (ECP, or RNase 3). It is also the shortest member of the human family, with a significan ...[more]