Ontology highlight
ABSTRACT:
SUBMITTER: Beckert U
PROVIDER: S-EPMC4764875 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Beckert Urike U Wolter Sabine S Hartwig Christina C Bähre Heike H Kaever Volkhard V Ladant Daniel D Frank Dara W DW Seifert Roland R
Biochemical and biophysical research communications 20140624 1
In addition to the well known second messengers cAMP and cGMP, mammalian cells contain the cyclic pyrimidine nucleotides cCMP and cUMP. Soluble guanylyl cyclase and soluble adenylyl cyclase produce all four cNMPs. Several bacterial toxins exploit mammalian cyclic nucleotide signaling. The type III secretion protein ExoY from Pseudomonas aeruginosa induces severe lung damage and effectively produces cGMP. Here, we show that transfection of mammalian cells with ExoY or infection with ExoY-expressi ...[more]