Contribution of ENPP1, TCF7L2, and FTO polymorphisms to type 2 diabetes in mixed ancestry ethnic population of South Africa.

ABSTRACT:

Background

Transcription factor 7-like 2 gene (TCF7L2), fat mass and obesity-associated gene (FTO), and ectonucleotide pyrophosphatase/phosphodiesterase gene (ENPP1) are known risk loci for type 2 diabetes (T2DM) mostly in European populations.

Objectives

To assess the association of these genes with T2DM risk in a South African mixed-ancestry population.

Methods

Five hundred and sixty six participants were genotyped for ENPP1-rs997509 and -rs1044498, FTO-9941349 and -rs3751812, TCF7L2-rs12255372 and -rs7903146 polymorphisms using Taqman genotyping assays and validated by automated sequencing to assess the association of the polymorphisms with cardiometabolic traits.

Results

In logistic regression models adjusted for age, sex, body mass index (BMI) and insulin

SUBMITTER: Yako YY 

PROVIDER: S-EPMC4765404 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature