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Novel Controlled Release Polymer-Lipid Formulations Processed by Hot Melt Extrusion.


ABSTRACT: The aim of the study was to investigate the effect of novel polymer/lipid formulations on the dissolution rates of the water insoluble indomethacin (INM), co-processed by hot melt extrusion (HME). Formulations consisted of the hydrophilic hydroxypropyl methyl cellulose polymer (HPMCAS) and stearoyl macrogol-32 glycerides-Gelucire 50/13 (GLC) were processed with a twin screw extruder to produce solid dispersions. The extrudates characterized by X-ray powder diffraction (XRPD), differential scanning calorimetry (DSC) and hot stage microscopy (HSM) indicated the presence of amorphous INM within the polymer/lipid matrices. In-line monitoring via near-infrared (NIR) spectroscopy revealed significant peak shifts indicating possible interactions and H-bonding formation between the drug and the polymer/lipid carriers. Furthermore, in vitro dissolution studies showed a synergistic effect of the polymer/lipid carrier with 2-h lag time in acidic media followed by enhanced INM dissolution rates at pH?>?5.5.

SUBMITTER: Maniruzzaman M 

PROVIDER: S-EPMC4766126 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature

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Novel Controlled Release Polymer-Lipid Formulations Processed by Hot Melt Extrusion.

Maniruzzaman Mohammed M   Islam Muhammad T MT   Halsey Sheelagh S   Amin Devyani D   Douroumis Dennis D  

AAPS PharmSciTech 20151221 1


The aim of the study was to investigate the effect of novel polymer/lipid formulations on the dissolution rates of the water insoluble indomethacin (INM), co-processed by hot melt extrusion (HME). Formulations consisted of the hydrophilic hydroxypropyl methyl cellulose polymer (HPMCAS) and stearoyl macrogol-32 glycerides-Gelucire 50/13 (GLC) were processed with a twin screw extruder to produce solid dispersions. The extrudates characterized by X-ray powder diffraction (XRPD), differential scanni  ...[more]

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