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ABSTRACT:
SUBMITTER: Maniruzzaman M
PROVIDER: S-EPMC4766126 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Maniruzzaman Mohammed M Islam Muhammad T MT Halsey Sheelagh S Amin Devyani D Douroumis Dennis D
AAPS PharmSciTech 20151221 1
The aim of the study was to investigate the effect of novel polymer/lipid formulations on the dissolution rates of the water insoluble indomethacin (INM), co-processed by hot melt extrusion (HME). Formulations consisted of the hydrophilic hydroxypropyl methyl cellulose polymer (HPMCAS) and stearoyl macrogol-32 glycerides-Gelucire 50/13 (GLC) were processed with a twin screw extruder to produce solid dispersions. The extrudates characterized by X-ray powder diffraction (XRPD), differential scanni ...[more]