Ontology highlight
ABSTRACT:
SUBMITTER: Singh P
PROVIDER: S-EPMC4766361 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Singh Parmveer P Irwin David M DM
PloS one 20160224 2
ChREBP and MondoA are glucose-sensitive transcription factors that regulate aspects of energy metabolism. Here we performed a phylogenomic analysis of Mlxip (encoding MondoA) and Mlxipl (encoding ChREBP) genes across vertebrates. Analysis of extant Mlxip and Mlxipl genes suggests that the most recent common ancestor of these genes was composed of 17 coding exons. Single copy genes encoding both ChREBP and MondoA, along with their interacting partner Mlx, were found in diverse vertebrate genomes, ...[more]