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Differential Proteomic Analysis of Human Saliva using Tandem Mass Tags Quantification for Gastric Cancer Detection.

ABSTRACT: Novel biomarkers and non-invasive diagnostic methods are urgently needed for the screening of gastric cancer to reduce its high mortality. We employed quantitative proteomics approach to develop discriminatory biomarker signatures from human saliva for the detection of gastric cancer. Salivary proteins were analyzed and compared between gastric cancer patients and matched control subjects by using tandem mass tags (TMT) technology. More than 500 proteins were identified with quantification, and 48 of them showed significant difference expression (p?

SUBMITTER: Xiao H

PROVIDER: S-EPMC4766442 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature

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Differential Proteomic Analysis of Human Saliva using Tandem Mass Tags Quantification for Gastric Cancer Detection.

Xiao Hua H Zhang Yan Y Kim Yong Y Kim Sung S Kim Jae Joon JJ Kim Kyoung Mee KM Yoshizawa Janice J Fan Liu-Yin LY Cao Cheng-Xi CX Wong David T W DT

Scientific reports 20160225

Novel biomarkers and non-invasive diagnostic methods are urgently needed for the screening of gastric cancer to reduce its high mortality. We employed quantitative proteomics approach to develop discriminatory biomarker signatures from human saliva for the detection of gastric cancer. Salivary proteins were analyzed and compared between gastric cancer patients and matched control subjects by using tandem mass tags (TMT) technology. More than 500 proteins were identified with quantification, and ...[more]

PMID: 26911362

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