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Epigenetic Silencing of the Key Antioxidant Enzyme Catalase in Karyotypically Abnormal Human Pluripotent Stem Cells.

ABSTRACT: Epigenomic regulation is likely to be important in the maintenance of genomic integrity of human pluripotent stem cells, however, the mechanisms are unknown. We explored the epigenomes and transcriptomes of human pluripotent stem cells before and after spontaneous transformation to abnormal karyotypes and in correlation to cancer cells. Our results reveal epigenetic silencing of Catalase, a key regulator of oxidative stress and DNA damage control in abnormal cells. Our findings provide novel insight into the mechanisms associated with spontaneous transformation of human pluripotent stem cells towards malignant fate. The same mechanisms may control the genomic stability of cells in somatic tissues.

SUBMITTER: Konki M

PROVIDER: S-EPMC4766493 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature

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Epigenetic Silencing of the Key Antioxidant Enzyme Catalase in Karyotypically Abnormal Human Pluripotent Stem Cells.

Konki Mikko M Pasumarthy Kalyan K Malonzo Maia M Sainio Annele A Valensisi Cristina C Söderström Mirva M Emani Maheswara Reddy MR Stubb Aki A Närvä Elisa E Ghimire Bishwa B Laiho Asta A Järveläinen Hannu H Lahesmaa Riitta R Lähdesmäki Harri H Hawkins R David RD Lund Riikka J RJ

Scientific reports 20160225

Epigenomic regulation is likely to be important in the maintenance of genomic integrity of human pluripotent stem cells, however, the mechanisms are unknown. We explored the epigenomes and transcriptomes of human pluripotent stem cells before and after spontaneous transformation to abnormal karyotypes and in correlation to cancer cells. Our results reveal epigenetic silencing of Catalase, a key regulator of oxidative stress and DNA damage control in abnormal cells. Our findings provide novel ins ...[more]

PMID: 26911679

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