Ontology highlight
ABSTRACT:
SUBMITTER: Toto A
PROVIDER: S-EPMC4766501 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Toto Angelo A Camilloni Carlo C Giri Rajanish R Brunori Maurizio M Vendruscolo Michele M Gianni Stefano S
Scientific reports 20160225
Intrinsically disordered proteins often become structured upon interacting with their partners. The mechanism of this 'folding upon binding' process, however, has not been fully characterised yet. Here we present a study of the folding of the intrinsically disordered transactivation domain of c-Myb (c-Myb) upon binding its partner KIX. By determining the structure of the folding transition state for the binding of wild-type and three mutational variants of KIX, we found a remarkable plasticity o ...[more]