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A novel peptide with potent and broad-spectrum antiviral activities against multiple respiratory viruses.


ABSTRACT: A safe, potent and broad-spectrum antiviral is urgently needed to combat emerging respiratory viruses. In light of the broad antiviral activity of ?-defensins, we tested the antiviral activity of 11 peptides derived from mouse ?-defensin-4 and found that a short peptide, P9, exhibited potent and broad-spectrum antiviral effects against multiple respiratory viruses in vitro and in vivo, including influenza A virus H1N1, H3N2, H5N1, H7N7, H7N9, SARS-CoV and MERS-CoV. The antiviral activity of P9 was attributed to its high-affinity binding to viral glycoproteins, as well as the abundance of basic amino acids in its composition. After binding viral particles through viral surface glycoproteins, P9 entered into cells together with the viruses via endocytosis and prevented endosomal acidification, which blocked membrane fusion and subsequent viral RNA release. This study has paved the avenue for developing new prophylactic and therapeutic agents with broad-spectrum antiviral activities.

SUBMITTER: Zhao H 

PROVIDER: S-EPMC4766503 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature

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A novel peptide with potent and broad-spectrum antiviral activities against multiple respiratory viruses.

Zhao Hanjun H   Zhou Jie J   Zhang Ke K   Chu Hin H   Liu Dabin D   Poon Vincent Kwok-Man VK   Chan Chris Chung-Sing CC   Leung Ho-Chuen HC   Fai Ng N   Lin Yong-Ping YP   Zhang Anna Jin-Xia AJ   Jin Dong-Yan DY   Yuen Kwok-Yung KY   Zheng Bo-Jian BJ  

Scientific reports 20160225


A safe, potent and broad-spectrum antiviral is urgently needed to combat emerging respiratory viruses. In light of the broad antiviral activity of β-defensins, we tested the antiviral activity of 11 peptides derived from mouse β-defensin-4 and found that a short peptide, P9, exhibited potent and broad-spectrum antiviral effects against multiple respiratory viruses in vitro and in vivo, including influenza A virus H1N1, H3N2, H5N1, H7N7, H7N9, SARS-CoV and MERS-CoV. The antiviral activity of P9 w  ...[more]

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