Ontology highlight
ABSTRACT:
SUBMITTER: Martin-Acebes MA
PROVIDER: S-EPMC4766991 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Journal of lipid research 20160113 3
Flaviviruses, such as the dengue virus and the West Nile virus (WNV), are arthropod-borne viruses that represent a global health problem. The flavivirus lifecycle is intimately connected to cellular lipids. Among the lipids co-opted by flaviviruses, we have focused on SM, an important component of cellular membranes particularly enriched in the nervous system. After infection with the neurotropic WNV, mice deficient in acid sphingomyelinase (ASM), which accumulate high levels of SM in their tiss ...[more]