Estrogen Receptor Alpha (ESR1) Single-Nucleotide Polymorphisms (SNPs) Affect Malignant Melanoma Susceptibility and Disease Course.
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ABSTRACT:
SUBMITTER: Glatthaar H
PROVIDER: S-EPMC4767130 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
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Estrogen Receptor Alpha (ESR1) Single-Nucleotide Polymorphisms (SNPs) Affect Malignant Melanoma Susceptibility and Disease Course.
Glatthaar Hanna H Katto Judith J Vogt Thomas T Mahlknecht Ulrich U
Genetics & epigenetics 20160224
The incidence of malignant melanoma in the developed world is continuously increasing. We conducted a case-control study in order to evaluate the association between each of the four estrogen receptor alpha polymorphisms (ESR1 single-nucleotide polymorphisms [SNPs] +2464C/T, -4576A/C, +1619A/G, and +6362C/T) and malignant melanoma susceptibility and disease course. The study population consisted of 205 Caucasian patients who were diagnosed as having malignant melanoma and 208 healthy Caucasian c ...[more]
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