Overexpression of microRNA-99a Attenuates Cardiac Hypertrophy.
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ABSTRACT:
SUBMITTER: Li Q
PROVIDER: S-EPMC4767297 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Publications
Overexpression of microRNA-99a Attenuates Cardiac Hypertrophy.
Li Qiaoling Q Xie Jun J Wang Bingjian B Li Ran R Bai Jian J Ding Liang L Gu Rong R Wang Lian L Xu Biao B
PloS one 20160225 2
Pathological cardiomyocyte hypertrophy is associated with significantly increased risk of heart failure, one of the leading medical causes of mortality worldwide. MicroRNAs are known to be involved in pathological cardiac remodeling. However, whether miR-99a participates in the signaling cascade leading to cardiac hypertrophy is unknown. To evaluate the role of miR-99a in cardiac hypertrophy, we assessed the expression of miR-99a in hypertrophic cardiomyocytes induced by isoprenaline (ISO)/angio ...[more]
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