Ontology highlight
ABSTRACT:
SUBMITTER: Malanga D
PROVIDER: S-EPMC4767462 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Malanga Donatella D De Marco Carmela C Guerriero Ilaria I Colelli Fabiana F Rinaldo Nicola N Scrima Marianna M Mirante Teresa T De Vitis Claudia C Zoppoli Pietro P Ceccarelli Michele M Riccardi Miriam M Ravo Maria M Weisz Alessandro A Federico Antonella A Franco Renato R Rocco Gaetano G Mancini Rita R Rizzuto Antonia A Gulletta Elio E Ciliberto Gennaro G Viglietto Giuseppe G
Oncotarget 20151201 40
Here we report that the PI3K/Akt1/IL-6/STAT3 signalling pathway regulates generation and stem cell-like properties of Non-Small Cell Lung Cancer (NSCLC) tumor initiating cells (TICs). Mutant Akt1, mutant PIK3CA or PTEN loss enhances formation of lung cancer spheroids (LCS), self-renewal, expression of stemness markers and tumorigenic potential of human immortalized bronchial cells (BEAS-2B) whereas Akt inhibition suppresses these activities in established (NCI-H460) and primary NSCLC cells. Matc ...[more]