Differential Regulation of Interferon Responses by Ebola and Marburg Virus VP35 Proteins.
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ABSTRACT:
SUBMITTER: Edwards MR
PROVIDER: S-EPMC4767585 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Publications
Differential Regulation of Interferon Responses by Ebola and Marburg Virus VP35 Proteins.
Edwards Megan R MR Liu Gai G Mire Chad E CE Sureshchandra Suhas S Luthra Priya P Yen Benjamin B Shabman Reed S RS Leung Daisy W DW Messaoudi Ilhem I Geisbert Thomas W TW Amarasinghe Gaya K GK Basler Christopher F CF
Cell reports 20160211 7
Suppression of innate immune responses during filoviral infection contributes to disease severity. Ebola (EBOV) and Marburg (MARV) viruses each encode a VP35 protein that suppresses RIG-I-like receptor signaling and interferon-α/β (IFN-α/β) production by several mechanisms, including direct binding to double stranded RNA (dsRNA). Here, we demonstrate that in cell culture, MARV infection results in a greater upregulation of IFN responses as compared to EBOV infection. This correlates with differe ...[more]
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