Ontology highlight
ABSTRACT:
SUBMITTER: Hutcheson JD
PROVIDER: S-EPMC4767675 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Nature materials 20160111 3
Clinical evidence links arterial calcification and cardiovascular risk. Finite-element modelling of the stress distribution within atherosclerotic plaques has suggested that subcellular microcalcifications in the fibrous cap may promote material failure of the plaque, but that large calcifications can stabilize it. Yet the physicochemical mechanisms underlying such mineral formation and growth in atheromata remain unknown. Here, by using three-dimensional collagen hydrogels that mimic structural ...[more]