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Suggested Cut-Off Values for Vitamin D as a Risk Marker for Total and Cardiac Death in Patients with Suspected Acute Coronary Syndrome.

ABSTRACT: BACKGROUND:Several studies have demonstrated an association between low vitamin D levels and cardiovascular risk. Vitamin D cut-off levels are still under debate. OBJECTIVES:To assess two cut-off levels, 40 and 70?nmol/L, respectively, for vitamin D measured as 25-hydroxyvitamin D in chest pain patients with suspected acute coronary syndrome. METHODS:We investigated 1853 patients from coastal-Norway and inland Northern-Argentina. A similar database was used for pooling of data. Two-year follow-up data including all-cause mortality, cardiac death, and sudden cardiac death in the total patient population were analyzed, applying univariate and multivariable analysis. RESULTS:Two hundred fifty-five patients with known vitamin D concentrations died. In the multivariable analysis, there was a decrease in total mortality above a cut-off level of 40?nmol/L and a decrease in cardiac death above a cut-off level of 70?nmol/L [HRs of 0.66 (95% CI, 0.50-0.88), p?=?0.004 and 0.46 (95% CI, 0.22-0.94), p?=?0.034, respectively]. CONCLUSION:Vitamin D cut-off levels of 40 and 70?nmol/L were related to total mortality and cardiac death, respectively.

SUBMITTER: Naesgaard PA

PROVIDER: S-EPMC4767896 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature

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Suggested Cut-Off Values for Vitamin D as a Risk Marker for Total and Cardiac Death in Patients with Suspected Acute Coronary Syndrome.

Naesgaard Patrycja A PA León de la Fuente Ricardo A RA Nilsen Stein Tore ST Pönitz Volker V Brügger-Andersen Trygve T Grundt Heidi H Staines Harry H Nilsen Dennis W T DW

Frontiers in cardiovascular medicine 20160226

<h4>Background</h4>Several studies have demonstrated an association between low vitamin D levels and cardiovascular risk. Vitamin D cut-off levels are still under debate.<h4>Objectives</h4>To assess two cut-off levels, 40 and 70 nmol/L, respectively, for vitamin D measured as 25-hydroxyvitamin D in chest pain patients with suspected acute coronary syndrome.<h4>Methods</h4>We investigated 1853 patients from coastal-Norway and inland Northern-Argentina. A similar database was used for pooling of d ...[more]

PMID: 26955633

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Dataset Information

Suggested Cut-Off Values for Vitamin D as a Risk Marker for Total and Cardiac Death in Patients with Suspected Acute Coronary Syndrome.

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Suggested Cut-Off Values for Vitamin D as a Risk Marker for Total and Cardiac Death in Patients with Suspected Acute Coronary Syndrome.

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