Ontology highlight
ABSTRACT:
SUBMITTER: Navarro MN
PROVIDER: S-EPMC4768351 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Navarro María N MN Feijoo-Carnero Carmen C Arandilla Alba Gonzalez AG Trost Matthias M Cantrell Doreen A DA
Science signaling 20141021 348
Protein kinase D2 (PKD2) is a serine and threonine kinase that is activated in T cells by diacylglycerol and protein kinase C in response to stimulation of the T cell receptor (TCR) by antigen. We quantified the activation of PKD2 at the single-cell level and found that this kinase acts as a sensitive digital amplifier of TCR engagement, enabling CD8(+) T cells to match the production of inflammatory cytokines to the quality and quantity of TCR ligands. There was a digital response pattern of PK ...[more]