Ontology highlight
ABSTRACT:
SUBMITTER: Song ZL
PROVIDER: S-EPMC4768722 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Song Zi-Long ZL Chen Hai-Le HL Wang Yu-Han YH Goto Masuo M Gao Wen-Jing WJ Cheng Pi-Le PL Morris-Natschke Susan L SL Liu Ying-Qian YQ Zhu Gao-Xiang GX Wang Mei-Juan MJ Lee Kuo-Hsiung KH
Bioorganic & medicinal chemistry letters 20150506 13
In our continuing search for camptothecin (CPT)-derived antitumor drugs, novel structurally diverse PEG-based 20(S)-CPT sulfonylamidine derivatives were designed, synthesized via a Cu-multicomponent reaction (MCR), and evaluated for cytotoxicity against four human tumor cell lines (A-549, MDA-MB-231, KB, and KBvin). All of the derivatives showed promising in vitro cytotoxic activity against the tested tumor cell lines, and were more potent than irinotecan. Significantly, these derivatives exhibi ...[more]