Ontology highlight
ABSTRACT:
SUBMITTER: Liu J
PROVIDER: S-EPMC4768733 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Liu Junli J Lee Jaemin J Salazar Hernandez Mario Andres MA Mazitschek Ralph R Ozcan Umut U
Cell 20150501 5
Despite all modern advances in medicine, an effective drug treatment of obesity has not been found yet. Discovery of leptin two decades ago created hopes for treatment of obesity. However, development of leptin resistance has been a big obstacle, mitigating a leptin-centric treatment of obesity. Here, by using in silico drug-screening methods, we discovered that Celastrol, a pentacyclic triterpene extracted from the roots of Tripterygium Wilfordi (thunder god vine) plant, is a powerful anti-obes ...[more]