Bacterial multidrug efflux transporters.
Ontology highlight
ABSTRACT:
SUBMITTER: Delmar JA
PROVIDER: S-EPMC4769028 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Publications
Bacterial multidrug efflux transporters.
Delmar Jared A JA Su Chih-Chia CC Yu Edward W EW
Annual review of biophysics 20140101
Infections caused by bacteria are a leading cause of death worldwide. Although antibiotics remain a key clinical therapy, their effectiveness has been severely compromised by the development of drug resistance in bacterial pathogens. Multidrug efflux transporters--a common and powerful resistance mechanism--are capable of extruding a number of structurally unrelated antimicrobials from the bacterial cell, including antibiotics and toxic heavy metal ions, facilitating their survival in noxious en ...[more]
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