Ontology highlight
ABSTRACT:
SUBMITTER: Forst AL
PROVIDER: S-EPMC4769195 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Forst Anna-Lena AL Olteanu Vlad Sorin VS Mollet Géraldine G Wlodkowski Tanja T Schaefer Franz F Dietrich Alexander A Reiser Jochen J Gudermann Thomas T Mederos y Schnitzler Michael M Storch Ursula U
Journal of the American Society of Nephrology : JASN 20150709 3
Podocytes are specialized, highly differentiated epithelial cells in the kidney glomerulus that are exposed to glomerular capillary pressure and possible increases in mechanical load. The proteins sensing mechanical forces in podocytes are unconfirmed, but the classic transient receptor potential channel 6 (TRPC6) interacting with the MEC-2 homolog podocin may form a mechanosensitive ion channel complex in podocytes. Here, we observed that podocytes respond to mechanical stimulation with increas ...[more]