Ontology highlight
ABSTRACT:
SUBMITTER: Thadhani R
PROVIDER: S-EPMC4769204 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Thadhani Ravi R Hagmann Henning H Schaarschmidt Wiebke W Roth Bernhard B Cingoez Tuelay T Karumanchi S Ananth SA Wenger Julia J Lucchesi Kathryn J KJ Tamez Hector H Lindner Tom T Fridman Alexander A Thome Ulrich U Kribs Angela A Danner Marco M Hamacher Stefanie S Mallmann Peter P Stepan Holger H Benzing Thomas T
Journal of the American Society of Nephrology : JASN 20150924 3
Preeclampsia is a devastating complication of pregnancy. Soluble Fms-like tyrosine kinase-1 (sFlt-1) is an antiangiogenic protein believed to mediate the signs and symptoms of preeclampsia. We conducted an open pilot study to evaluate the safety and potential efficacy of therapeutic apheresis with a plasma-specific dextran sulfate column to remove circulating sFlt-1 in 11 pregnant women (20-38 years of age) with very preterm preeclampsia (23-32 weeks of gestation, systolic BP ≥140 mmHg or diasto ...[more]