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Genetic variants associated with neurodegenerative Alzheimer disease in natural models.


ABSTRACT: The use of transgenic models for the study of neurodegenerative diseases has made valuable contributions to the field. However, some important limitations, including protein overexpression and general systemic compensation for the missing genes, has caused researchers to seek natural models that show the main biomarkers of neurodegenerative diseases during aging. Here we review some of these models-most of them rodents, focusing especially on the genetic variations in biomarkers for Alzheimer diseases, in order to explain their relationships with variants associated with the occurrence of the disease in humans.

SUBMITTER: Salazar C 

PROVIDER: S-EPMC4769573 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature

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Genetic variants associated with neurodegenerative Alzheimer disease in natural models.

Salazar Claudia C   Valdivia Gonzalo G   Ardiles Álvaro O ÁO   Ewer John J   Palacios Adrián G AG  

Biological research 20160226


The use of transgenic models for the study of neurodegenerative diseases has made valuable contributions to the field. However, some important limitations, including protein overexpression and general systemic compensation for the missing genes, has caused researchers to seek natural models that show the main biomarkers of neurodegenerative diseases during aging. Here we review some of these models-most of them rodents, focusing especially on the genetic variations in biomarkers for Alzheimer di  ...[more]

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