Ontology highlight
ABSTRACT:
SUBMITTER: Salazar C
PROVIDER: S-EPMC4769573 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Salazar Claudia C Valdivia Gonzalo G Ardiles Álvaro O ÁO Ewer John J Palacios Adrián G AG
Biological research 20160226
The use of transgenic models for the study of neurodegenerative diseases has made valuable contributions to the field. However, some important limitations, including protein overexpression and general systemic compensation for the missing genes, has caused researchers to seek natural models that show the main biomarkers of neurodegenerative diseases during aging. Here we review some of these models-most of them rodents, focusing especially on the genetic variations in biomarkers for Alzheimer di ...[more]