Ontology highlight
ABSTRACT:
SUBMITTER: Jarapula R
PROVIDER: S-EPMC4769772 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Jarapula Ravi R Gangarapu Kiran K Manda Sarangapani S Rekulapally Sriram S
International journal of medicinal chemistry 20160214
A novel synthesis of 2-hydroxy-N'-(2-oxoindolin-3-ylidene) benzohydrazide derivatives was synthesized by the condensation of 2-hydroxybenzohydrazide with substituted isatins. The synthesized compounds were characterized by FT-IR, (1)H-NMR, and mass spectral data. Further, the compounds were screened for in vivo anti-inflammatory activity by carrageenan induced paw edema method. The tested compounds have shown mild-to-moderate anti-inflammatory activity. The compounds VIIc and VIId exhibited 65% ...[more]