Ontology highlight
ABSTRACT:
SUBMITTER: Merlevede J
PROVIDER: S-EPMC4770084 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Nature communications 20160224
The cytidine analogues azacytidine and 5-aza-2'-deoxycytidine (decitabine) are commonly used to treat myelodysplastic syndromes, with or without a myeloproliferative component. It remains unclear whether the response to these hypomethylating agents results from a cytotoxic or an epigenetic effect. In this study, we address this question in chronic myelomonocytic leukaemia. We describe a comprehensive analysis of the mutational landscape of these tumours, combining whole-exome and whole-genome se ...[more]